Matthew Stafford, Lions, tossed four touchdown passes and went 29 of 41 for 292 yards with an interception in his first game as the NFL's highest-paid player to lead Detroit to a 35-23 victory over Arizona.
Matt Ryan, Falcons, threw for 321 yards and a touchdown in Atlanta's 23-17 win at Chicago.
Carson Wentz, Eagles, passed for 307 yards and two scores to help Philadelphia top Washington 30-17.
Jared Goff, Rams, went 21 of 29 for a career-high 306 yards and a touchdown in Los Angeles' 46-9 rout of Indianapolis.
Derek Carr, Raiders, had 262 yards passing and two touchdowns in Oakland's 26-16 win at Tennessee – his first game since breaking his right leg late last season.
Leonard Fournette, Jaguars, had 100 yards rushing and a touchdown on 26 attempts in his NFL debut to help Jacksonville to a 29-7 win at Houston.
Terrance West, Ravens, ran for 80 yards and a TD on 19 carries in Baltimore's 20-0 victory at Cincinnati.
Marshawn Lynch, Raiders, had 76 yards rushing on 18 attempts in his first regular-season game since coming out of retirement.
Antonio Brown, Steelers, caught 11 passes for 182 yards in Pittsburgh's 21-18 win at Cleveland.
Golden Tate, Lions, had 10 receptions for 107 yards.
Kenny Golladay, Lions, caught two TD passes in his NFL debut.
Nelson Agholor, Eagles, had 86 yards receiving, including a 58-yard TD.
Austin Hooper, Falcons, had 128 yards receiving and a TD on two catches.
Giorgio Tavecchio, Raiders, kicked field goals of 20, 52, 52 and 43 yards in his NFL debut.
Matt Prater, Lions, made a 58-yard field goal and averaged 34.8 yards on four punts – with a long of 47 – in relief of the injured Kasey Redfern.
Greg Zuerlein, Rams, made all three of his field-goal attempts and five extra points.
Matt Bryant, Falcons, booted three field goals and two extra points.
Calais Campbell and Yannick Ngakoue, Jaguars. Campbell had four of Jacksonville's franchise-record 10 sacks. Ngakoue had two sacks and forced two fumbles.
Ryan Kerrigan, Washington, returned an interception of Carson Wentz 24 yards for a touchdown.
Brandon Graham, Eagles, had two sacks and forced a fumble.
Terrell Suggs, Ravens, sacked Cincinnati's Andy Dalton twice and forced a fumble in Baltimore's 20-0 win.
T.J. Watt, Steelers. The little brother of J.J. Watt had two sacks and an interception in his NFL debut.
Justin Bethel, Cardinals, returned Matthew Stafford's first pass 82 yards for a touchdown.
– Associated Press