Jared Goff, Rams, passed for a career-high 355 yards and four touchdowns to lead Los Angeles to its fourth straight victory, 33-7 over Houston.
Case Keenum, Vikings, threw touchdowns to four different receivers to build a big lead, and NFC North-leading Minnesota won its fifth in a row by beating Washington 38-30.
Matthew Stafford, Lions, threw three touchdown passes in the second half to help Detroit come back and beat winless Cleveland 38-24.
Marcus Mariota, Titans, tossed a 7-yard touchdown pass to DeMarco Murray with 36 seconds left and Tennessee rallied to beat Cincinnati 24-20 for its fourth consecutive victory.
C.J. Beathard, 49ers, threw for 288 yards and two touchdowns and ran for a third score to lead San Francisco to its first win of the season with a 31-21 victory over the New York Giants.
Ben Roethlisberger, Steelers, threw two second-half touchdown passes to erase a 14-point deficit and help Pittsburgh top Indianapolis 20-17.
Mark Ingram, Saints, had 131 yards rushing and scored three times in New Orleans' 47-10 victory at Buffalo.
DeMarco Murray, Titans, ran for two touchdowns and also caught a 7-yard TD pass with 36 seconds left.
Alvin Kamara, Saints, ran for 106 yards and a touchdown on 12 carries and also caught five passes for 32 yards.
Isaiah Crowell, Browns, had a season-high 90 yards and a score on 16 carries.
Carlos Hyde, 49ers, rushed for 98 yards on 17 attempts.
Adam Thielen, Vikings, had eight catches for a season-high 166 yards.
Michael Thomas, Saints, caught nine passes for 117 yards.
Robert Woods, Rams, finished with eight catches for 171 yards, including a career-best 94-yard TD reception.
Austin Ekeler, Chargers, had two touchdown catches in Los Angeles' 20-17 overtime loss at Jacksonville.
Sterling Shepard, Giants, caught 11 passes for 142 yards.
Josh Lambo, Jaguars, made a 30-yard field goal with 3:12 left in overtime.
Chris Boswell, Steelers, kicked a 33-yard field goal as time expired for victory.
Corey Grant, Jaguars, ran for a 56-yard touchdown on a fake punt.
Greg Zuerlein, Rams, kicked four field goals.
Corey Liuget, Chargers, blocked an extra-point attempt in the first quarter, the first blocked PAT for the Chargers since 2001.
Nevin Lawson, Lions, forced a fumble, recovered it and ran it into the end zone 44 yards.
Nick Perry, Packers, had three sacks to help Green Bay beat Chicago 23-16 and snap a three-game losing streak.
Tre Boston, Chargers, had two interceptions.
D.J. Swearinger, Washington, intercepted consecutive throws by Case Keenum.
– Associated Press