Latos gave up two runs in the fourth inning, ending his scoreless streak at 19 innings, as the Milwaukee Brewers beat the Reds 2-0 Saturday night.
Latos (12-4) allowed six hits over seven innings and fell two innings shy of his career-best stretch of 21, last accomplished April 19 to May 5.
"That one bad inning I hung a breaking ball, they hit a couple and two runs scored," he said. "That's just the way the game goes. Two runs will beat you on any given day."
The Reds threatened to score in the seventh inning as Brewers pitcher Yovani Gallardo gave up a one-out single to Brandon Phillips. Gallardo was replaced by Brandon Kintzler, who gave up consecutive singles to Jay Bruce and Ryan Ludwick. But Kintzler got pinch-hitter Xavier Paul to ground into a double play to end the inning.
Reds manager Dusty Baker said he felt good about the pitching matchup.
"We had the right guy up there against the right kind of pitcher. He hit the ball hard, but right to him and it's a double play," Baker said.
Baker said Cincinnati hitters did not give Latos much room for error.
"He had some trouble out there and his pitch count got kind of high in the middle but he gave us a chance to win," he said. "We had bases loaded a couple times, but we couldn't keep the ball off the ground, hitting into a double play."
While Latos was good, Gallardo (9-9) was better. Gallardo, who came off the disabled list Friday, gave up just three hits and struck out three to lead Milwaukee to its second straight win over the Reds.
Gallardo did not give up a hit until the fourth inning when Phillips singled after Joey Votto walked. But Phillips was caught in a rundown after the ball got away from Brewers catcher Jonathan Lucroy.
Reds third baseman Todd Frazier said Gallardo was getting his slider over the plate.
"His slider was probably his most effective pitch," he said. "It's about the same speed as the fastball so you've got to pick one out and a lot of the times we were just getting the wrong pitch to hit. You tip your cap to him. That's all you can do."
Gallardo (9-9) is in the midst of his worst season, posting a career high in ERA. He's also lost five of his last seven home starts with a 6.25 ERA prior to Saturday.
"Obviously it has not been the year I wanted to have," he said. "But that is in the past. My focus is on finishing the season strong and today was a good step forward."
Kintzler pitched a scoreless eighth inning and Jim Henderson struck out the side in the ninth for his 18th save in 21 chances.
The Brewers scored the only runs of the game in the fourth inning. Khris Davis and Scooter Bennett singled with two outs. Logan Schafer followed with a double to right field to score both runners. Schafer's double broke an 0-for-21 slump.
Notes: Ludwick got his first hit of the season in the fifth inning. He returned to the lineup this week after missing most of the season with a right shoulder injury. ... RHP Homer Bailey (7-10) will start for the Reds in the series finale on Sunday against the Brewers' Wily Peralta (8-12).